In 1698, the British doctor John Floyer wrote asthma treatment, the first major work looked at the disease. Not all are well aged. He warned that those who were sad or angry often face threats, because grief eliminates “Trials.” He also recommended a number of treatments in addition to frequent vomiting.
In the case of asthma, the air that passes through a person’s lungs becomes blocked, making it difficult for him to breathe and causing chest tightness, coughing, and shortness of breath. But Floyer’s piece also mentioned another important sign: His asthma tends to be severe at night, sometimes waking him up 1 or 2 in the morning. Centuries later, scientists were finding convincing evidence: A study from 2005 found that almost 75 percent People with asthma experience problems at night. A popular study of deaths in London’s hospitals during the 1970’s showed that there were early morning and night outbreaks. very dangerous lethal.
However, no one knows why asthma develops at night, says Steven Shea, director of the Oregon Institute of Occupational Health Sciences at Oregon Health and Science University. “Most people sleep at night, so it’s probably the sleep that causes your asthma at night,” he says. Or it may be triggered by the appearance of an animal or a mite or a secretive allergen. Or, Shea adds, “it’s probably an internal clock.”
The body clock is also known as the circadian system. Among other things, it regulates hormones, heart rate, and immune system activity over a period of about 24 hours. work schedule.
In the past, it was impossible to distinguish the part of the environment surrounded by human behavior and environmental hazards “because they are intertwined,” says Frank Scheer, director of Medical Chronobiology Program at Brigham and Women Hospital. You may not know what is causing the lung changes. ”But inside paper published this month in Growth of the National Academy of Science, a team led by Scheer and Shea eventually found a way to solve the circadian system on all external factors that could cause asthma.
First, they had 17 participants, all of whom were diagnosed with asthma, monitoring their lung function at home in their daily lives. Four times a day, the students use a hand-held device to measure the amount of air that they can expel from their lungs for one second, a measure called FEV1. (Extras, that’s fine.) He also wrote down what he knew and realized when he had to use the rescuers.
Eventually, things got worse. The same group of participants were tested in two ways by trying to stay in a light place at the Center for Critical Inquiry at Brigham and Women Hospital. In one experiment, the so-called “regular program,” students stayed in bed for 38 hours without sleeping. She could not get up to swim or do anything tricky. Every two hours, eat the same yeast, a little peanut butter and jelly or a fish sandwich. They were allowed to listen to literature on tape, chat with nurses, or play card games, but they could not move around or have fun or get angry.
In these rooms without clocks or windows, and since the lessons are not connected to their daily activities or home spaces, outside time feels like no more. The students did not know when the sun rises or sets, when it is time for lunch, or when it is time to go to bed.